BDBM652750 8-methoxy-N5-((2-((1-methylpiperidin-4-yl)methoxy)pyridin-4-yl)methyl)isoquinoline- 1,5-diamine::US20240059691, Example 4470

SMILES COc1ccc(NCc2ccnc(OCC3CCN(C)CC3)c2)c2ccnc(N)c12

InChI Key InChIKey=OBRMYBVETQYTBA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652750   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652750BDBM652750(US20240059691, Example 4470 | 8-methoxy-N5-((2-((1...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652750BDBM652750(US20240059691, Example 4470 | 8-methoxy-N5-((2-((1...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent