BDBM654785 3-(1-isopropyl-1H-indol-5-yl)-5-(2- methoxyphenyl)-1,2,4-oxadiazole::US11912693, Compound 398

SMILES COc1ccccc1-c1nc(no1)-c1ccc2n(ccc2c1)C(C)C

InChI Key InChIKey=MMYMBBSSCVFQLX-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 654785   

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654785(US11912693, Compound 398 | 3-(1-isopropyl-1H-indol...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandPNGBDBM654785(US11912693, Compound 398 | 3-(1-isopropyl-1H-indol...)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist-promoted β-arrestin2 recruitment to the sphingosine-1-phosphate 1 receptor was determined using the β-arrestin PathHunter ) Detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Trevena

US Patent
LigandPNGBDBM654785(US11912693, Compound 398 | 3-(1-isopropyl-1H-indol...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Trevena

US Patent
LigandPNGBDBM654785(US11912693, Compound 398 | 3-(1-isopropyl-1H-indol...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Trevena

US Patent
LigandPNGBDBM654785(US11912693, Compound 398 | 3-(1-isopropyl-1H-indol...)
Affinity DataEC50: >1.00E+4nMAssay Description:S1P2 Agonist-promoted G-protein responses were determined by measuring changes in intracellular inositol monophosphate using the IP-one TB kit (CisBi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent