BDBM656776 5-Fluoro-N-isopropyl-N-((R)-tetrahydrofuran-3-yl)- 2-((4-(7-(((2S,5R)-5-((N-(2,2,2- trifluoroethyl)sulfamoyl)amino)tetrahydro-2H- pyran-2-yl)methyl)-2,7-diazaspiro[3.5]nonan-2- yl)pyrimidin-5-yl)oxy)benzamide::US11919901, Compound 171

SMILES CC(C)N([C@@H]1CCOC1)C(=O)c1cc(F)ccc1Oc1cncnc1N1CC2(C1)CCN(C[C@@H]1CC[C@H](CO1)NS(=O)(=O)NCC(F)(F)F)CC2

InChI Key InChIKey=PBESVYMYWKFCRI-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 656776   

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Syndax Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 656776BDBM656776(5-Fluoro-N-isopropyl-N-((R)-tetrahydrofuran-3-yl)-...)
Affinity DataKi: <1nMAssay Description:Table 4: For Ki determination, individual compounds were prepared as 10 mM DMSO stock solutions. Considering DMSO as the vehicle in the assay system....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2024
Entry Details
US Patent