BDBM656820 N-Ethyl-2-((4-(7-(((2S,5R)-5- (ethylsulfonamido)tetrahydro-2H-pyran-2- yl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)-2- methylpyrimidin-5-yl)oxy)-5-fluoro-N- isopropylbenzamide::US11919901, Compound 216

SMILES CCN(C(C)C)C(=O)c1cc(F)ccc1Oc1cnc(C)nc1N1CC2(C1)CCN(C[C@@H]1CC[C@H](CO1)NS(=O)(=O)CC)CC2

InChI Key InChIKey=LRUVGLUJXLOGAW-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 656820   

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Syndax Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 656820BDBM656820(N-Ethyl-2-((4-(7-(((2S,5R)-5- (ethylsulfonamido)te...)
Affinity DataKi:  1.25nMAssay Description:Table 4: For Ki determination, individual compounds were prepared as 10 mM DMSO stock solutions. Considering DMSO as the vehicle in the assay system....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2024
Entry Details
US Patent