BDBM665895 US20240116922, Comparator 2B

SMILES Cc1cnc2c(cnn2c1)NC(=O)c3cn4cc(nc4nc3OC(C)C)C56CC(C5)(OC6)C

InChI Key InChIKey=DEQCXGYERMCXNL-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 665895   

LigandPNGBDBM665895(US20240116922, Comparator 2B)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human IRAK4 using biotinylated peptide substrate incubated for 3 hrs by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM665895(US20240116922, Comparator 2B)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IRAK4 (unknown origin) using biotinylated peptide (IRAK1 activation loop sequence 360-389) as substrate incubated for 2 hrs in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM665895(US20240116922, Comparator 2B)
Affinity DataIC50: 0.800nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM665895(US20240116922, Comparator 2B)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details