BDBM667642 N-(2-ethyl-5-methyl-2,3- dihydro-1H-inden-1-yl)-2- oxo-6-(trifluoromethyl)-1,2- dihydropyridine-3- carboxamide::US11957687, Compound 298

SMILES CCC1Cc2cc(C)ccc2C1NC(=O)c1ccc([nH]c1=O)C(F)(F)F

InChI Key InChIKey=IMKVKAJSEJNBQH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 667642   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667642(N-(2-ethyl-5-methyl-2,3- dihydro-1H-inden-1-yl)-2-...)
Affinity DataIC50: 60nMAssay Description:Compounds of the disclosure were screened for their ability to block HSD17B13 function using an enzymatic blocking assay. HSD17B13 activity was quant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667642(N-(2-ethyl-5-methyl-2,3- dihydro-1H-inden-1-yl)-2-...)
Affinity DataIC50: 3.00E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B1 function, an enzymatic blocking assay was performed. For the assay, HSD17B1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667642(N-(2-ethyl-5-methyl-2,3- dihydro-1H-inden-1-yl)-2-...)
Affinity DataIC50: 3.09E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B2 function, an enzymatic blocking assay was performed. For the assay, HSD17B2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent