BDBM668626 2-[3-[[2-Fluoro-3-(methylsulfamoylamino)phenyl]methyl]-2-oxo-7-pyrimidin-2-yloxychromen-4-yl]-N-(2-hydroxyethoxy)acetamide::US11964950, Compound AA-2

SMILES CNS(=O)(=O)Nc1cccc(Cc2c(CC(=O)NOCCO)c3ccc(Oc4ncccn4)cc3oc2=O)c1F

InChI Key InChIKey=FUMSHCTVBNTKPB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 668626   

TargetSerine/threonine-protein kinase B-raf(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandChemical structure of BindingDB Monomer ID 668626BDBM668626(2-[3-[[2-Fluoro-3-(methylsulfamoylamino)phenyl]met...)
Affinity DataIC50: 2.20E+3nMAssay Description:The BRAF-inhibiting activity of the compounds listed in Table 3 below was evaluated by the time-resolved fluorescence-fluorescence resonance energy t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandChemical structure of BindingDB Monomer ID 668626BDBM668626(2-[3-[[2-Fluoro-3-(methylsulfamoylamino)phenyl]met...)
Affinity DataIC50: 8.00E+3nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent