BDBM669399 US11964973, Example 397::US11964973, Example 398::trans-8-(4-((5-Isopropoxypyridin-2-yl)oxy)-3-ethoxypiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile

SMILES CCO[C@H]1CN(CC[C@@H]1Oc1ccc(OC(C)C)cn1)c1cc(=O)n(C)c2ccc(nc12)C#N

InChI Key InChIKey=PPOOHXPJRQHGQB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 669399   

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM669399(US11964973, Example 397 | US11964973, Example 398 ...)
Affinity DataIC50: 420nMAssay Description:The DGKα and DGKζ reactions were performed using either extruded liposome (DGKα and DGKζ LIPGLO assays). The reactions were carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2024
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM669399(US11964973, Example 397 | US11964973, Example 398 ...)
Affinity DataIC50: 1.20E+3nMAssay Description:The DGKα and DGKζ reactions were performed using either extruded liposome (DGKα and DGKζ LIPGLO assays). The reactions were carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2024
Entry Details
US Patent