BDBM676369 US20240166635, Example 89

SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(n1)N1CCCCC1

InChI Key InChIKey=OCARTNNFCDDTMN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 676369   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Anrui Biomedical Technology (Guangzhou) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 676369BDBM676369(US20240166635, Example 89)
Affinity DataIC50: 55nMAssay Description:CDK2/CyclinE1 kinase inhibitory activity (IC50): 5 μl of various dilutions of test compounds in 1×kinase buffer (50 mM HEPES pH 7.5, 10 mM MgCl2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Anrui Biomedical Technology (Guangzhou) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 676369BDBM676369(US20240166635, Example 89)
Affinity DataIC50: 550nMAssay Description:CDK1/CyclinB kinase inhibitory activity (IC50): 5 μl of various dilutions of test compound in 1×kinase buffer (50 mM HEPES pH 7.5, 10 mM MgCl2, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Anrui Biomedical Technology (Guangzhou) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 676369BDBM676369(US20240166635, Example 89)
Affinity DataIC50: 1.00E+3nMAssay Description:CDK9/CyclinT1 kinase inhibitory activity (IC50): 5 l of various dilutions of test compound in 1×kinase buffer (20 mM HEPES, pH 7.5, 10 mM MgCl2, 2 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Anrui Biomedical Technology (Guangzhou) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 676369BDBM676369(US20240166635, Example 89)
Affinity DataIC50: 1.00E+3nMAssay Description:CDK7/Cyclin HIMAT1 kinase inhibitory activity (IC50): 5 l of various dilutions of test compound in 1×kinase buffer (20 mM HEPES, pH 7.5, 10 mM MgCl2,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent