BDBM677278 N4-((1S,2R)-2-fluorocyclopropyl)-N2-(1-(2-(methylsulfonyl)ethyl)-1H-indazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine (Example 198) and N4-((1S,2S)-2-fluorocyclopropyl)-N2-(1-(2-(methylsulfonyl)ethyl)-1-indazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine (Example 199)::US20240174647, Example 199

SMILES CS(=O)(=O)CCn1ncc2c(Nc3ncc(c(NC4C[C@@H]4F)n3)C(F)(F)F)cccc12

InChI Key InChIKey=BPYJVJNVYRITGJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 677278   

LigandPNGBDBM677278(US20240174647, Example 199 | N4-((1S,2R)-2-fluoroc...)
Affinity DataIC50: 50nMAssay Description:The protocol for basic TR-FRET LanthaScreen Tb Kinase Activity Assay inhibitor studies were as follows. LanthaScreen Kinase Activity Assays (ThermoFi...More data for this Ligand-Target Pair
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Date in BDB:
9/5/2024
Entry Details
US Patent