BDBM684651 US20240226107, Compound 63::US20240226107, Compound 64::US20240226107, Compound 68::US20240226107, Compound 70

SMILES COc1ncnc(C2CC2)c1-c1ncc2N(C)C(=O)C(C)N(Cc3ccc(-c4nc(cn4C)C(F)(F)F)c(F)c3)c2n1

InChI Key InChIKey=CBCKEDVDVYYONQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 684651   

TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
Simcere Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM684651(US20240226107, Compound 63 | US20240226107, Compou...)
Affinity DataIC50: 11.3nMAssay Description:Each compound to be tested was dissolved with DMSO to 10 mM. The compound and pure DMSO (with a total volume of 50 nL) were loaded to each well of th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
Simcere Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM684651(US20240226107, Compound 63 | US20240226107, Compou...)
Affinity DataIC50: 12.1nMAssay Description:Each compound to be tested was dissolved with DMSO to 10 mM. The compound and pure DMSO (with a total volume of 50 nL) were loaded to each well of th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
Simcere Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM684651(US20240226107, Compound 63 | US20240226107, Compou...)
Affinity DataIC50: 22.7nMAssay Description:Each compound to be tested was dissolved with DMSO to 10 mM. The compound and pure DMSO (with a total volume of 50 nL) were loaded to each well of th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 1(Human)
Simcere Zaiming Pharmaceutical Co.

US Patent
LigandPNGBDBM684651(US20240226107, Compound 63 | US20240226107, Compou...)
Affinity DataIC50: 37.9nMAssay Description:Each compound to be tested was dissolved with DMSO to 10 mM. The compound and pure DMSO (with a total volume of 50 nL) were loaded to each well of th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
Go to US Patent