BDBM684860 4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-4-fluoro-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-9,10-dihydro-8H-7-oxa-1,3,6,10-tetraazacyclohepta[de]naphthalen-5-yl)-6-methyl-5-(trifluoromethyl)pyridin-2-amine::US20240228512, Example 627

SMILES C[C@@H](N1CCOc2nc(c(F)c3nc(OC[C@@H]4CCCN4C)nc1c23)-c1cc(N)nc(C)c1C(F)(F)F)c1cccnc1N

InChI Key InChIKey=GJGHIDXNZWXQFG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 684860   

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684860(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-4-fluoro-...)
Affinity DataIC50: 0.440nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684860(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-4-fluoro-...)
Affinity DataIC50: 4.67nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent