BDBM685226 4-(2-((1-((dimethyl- amino)methyl)cyclo- propyl)methoxy)-6,8- difluoro-4-(6- methoxy-3,8- diazabicyclo[3.2.1]oc- tan-3-yl)quinazolin- 7-yl)naphthalen-2-ol::US20240239788, Example 25
SMILES COC1CC2CN(CC1N2)c1nc(OCC2(CN(C)C)CC2)nc2c(F)c(c(F)cc12)-c1cc(O)cc2ccccc12
InChI Key InChIKey=CLVFTSLBKXAZFW-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 685226
TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [G12D](Human)
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 2.03E+4nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair
