BDBM686486 3-(4-fluoro-1-oxo-5-(((1S,2S)-2- (3-phenylazetidin-1- yl)cyclohexyl)oxy)isoindolin-2- yl)piperidine-2,6-dione::US20240246935, Example 65::US20240246935, Example 66

SMILES Fc1c2CN(C3CCC(=O)NC3=O)C(=O)c2ccc1O[C@H]1CCCC[C@@H]1N1CC(C1)c1ccccc1

InChI Key InChIKey=RIQVFCDNSXZUJO-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 686486   

TargetProtein cereblon(Human)
Plexium, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 686486BDBM686486(US20240246935, Example 66 | 3-(4-fluoro-1-oxo-5-((...)
Affinity DataEC50:  24nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
Plexium, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 686486BDBM686486(US20240246935, Example 66 | 3-(4-fluoro-1-oxo-5-((...)
Affinity DataEC50:  52nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent