BDBM688403 US20240189315, Example P03 of PCT/EP2022/062480) (Prodrug of Ex. 1.12 of PCT/EP2022/062480)

SMILES COC(=O)[C@@H]1C[C@@H](CN1c1nc(nc2c3ccccc3oc12)C(F)(F)F)Oc1ncc(cc1N1CCOC2(COC2)[C@@H]1C)C#C

InChI Key InChIKey=VUOBGFYTSYQKMC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 688403   

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688403(US20240189315, Example P03 of PCT/EP2022/062480) (...)
Affinity DataIC50: 9.62E+3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688403(US20240189315, Example P03 of PCT/EP2022/062480) (...)
Affinity DataIC50: 9.62E+3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent