BDBM689243 5-[2-(2,2-difluoroethoxy)-4,4,4-trifluoro- butoxy]-3-methyl-N-(4-methyl-1,1-dioxo- thian-4-yl)imidazo[4,5-b]pyridine-2- carboxamide (faster eluting on SFC IG column, 23%/77% MeOH/CO2)::US20240254114, Example 63a

SMILES Cn1c(nc2ccc(OC[C@H](CC(F)(F)F)OCC(F)F)nc12)C(=O)NC1(C)CCS(=O)(=O)CC1

InChI Key InChIKey=ZKWKUFKZJINDSY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 689243   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM689243(US20240254114, Example 63a | 5-[2-(2,2-difluoroeth...)
Affinity DataIC50: 50nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
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Date in BDB:
11/20/2024
Entry Details
US Patent