BDBM693350 4-(2-(4- ((ethyl(methyl)sulfamoyl)amino)-2,3,5- trifluoro-phenoxy)-3-pyridyl)-2- (((3S,5S)-5-fluoro-3- piperidyl)amino)pyrimidine::US12071425, Compound 269

SMILES CCN(C)S(=O)(=O)Nc1c(F)cc(Oc2ncccc2-c2ccnc(N[C@@H]3CNC[C@@H](F)C3)n2)c(F)c1F

InChI Key InChIKey=OMWPRSJSMXOGDW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 693350   

LigandPNGBDBM693350(4-(2-(4- ((ethyl(methyl)sulfamoyl)amino)-2,3,5- tr...)
Affinity DataIC50: 1.10nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
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Date in BDB:
12/6/2024
Entry Details
US Patent