BDBM695835 (5S)-5-(3-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3 (2H)-yl)-3-oxopropyl)-5-cyclopropylimidazolidine-2,4-dione 8::US20240299360, Example 8

SMILES CC1CN(CCc2ccc(Cl)cc12)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1

InChI Key InChIKey=ZQBRQDVCSATBBO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 695835   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695835(US20240299360, Example 8 | (5S)-5-(3-(8-chloro-1-m...)
Affinity DataIC50: 53nMAssay Description:Table 2: In this assay, the enzymatic activity of recombinant ADAMTS-5 protein (catalog #2198-AD, R&D Systems) was assayed with a protein substrate, ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695835(US20240299360, Example 8 | (5S)-5-(3-(8-chloro-1-m...)
Affinity DataIC50: 66nMAssay Description:Table 1: A FRET (fluorescence resonance energy transfer) peptide was cleaved by recombinant ADAMTS-4 or ADAMTS-5 proteins into two separate fragments...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695835(US20240299360, Example 8 | (5S)-5-(3-(8-chloro-1-m...)
Affinity DataIC50: 130nMAssay Description:Table 2: In this assay, the enzymatic activity of recombinant ADAMTS-5 protein (catalog #2198-AD, R&D Systems) was assayed with a protein substrate, ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
US Patent