BDBM698119 BDBM698121::US20240317721, Example 3a

SMILES Cc1c(c(nn1[C@H]1CC2(C1)CN(C2)C(=O)C=C)N1CCC(C1)c1cccnc1)-c1c(Cl)c(C)cc2[nH]ncc12

InChI Key InChIKey=JGCVPSVBNAXXQF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698119   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698119(BDBM698121 | US20240317721, Example 3a)
Affinity DataIC50: 242nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698119(BDBM698121 | US20240317721, Example 3a)
Affinity DataIC50: 340nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent