BDBM699452 (S)-2-(3-(Actylamidomethyl)-1-(4- (trifluoromethoxy)phenyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)-2- hydroxyethyl acetate::US12110276, Compound 146

SMILES CC(=O)OC[C@@H](O)c1ccnc2n(nc(CNC(=O)C=C)c12)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=KXYNOANCDJETIF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699452   

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 699452BDBM699452((S)-2-(3-(Actylamidomethyl)-1-(4- (trifluoromethox...)
Affinity DataIC50: 28nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 699452BDBM699452((S)-2-(3-(Actylamidomethyl)-1-(4- (trifluoromethox...)
Affinity DataIC50: 40nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 699452BDBM699452((S)-2-(3-(Actylamidomethyl)-1-(4- (trifluoromethox...)
Affinity DataIC50: 66nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 699452BDBM699452((S)-2-(3-(Actylamidomethyl)-1-(4- (trifluoromethox...)
Affinity DataIC50: 2.80E+3nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent