BDBM699453 (S)-2-(3-(Acrylamidomethyl)-1-(4- (trifluoromethoxy)phenyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)-2- hydroxyethyl dihydrogen phosphate::US12110276, Compound 147

SMILES O[C@H](COP(O)(O)=O)c1ccnc2n(nc(CNC(=O)C=C)c12)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=RXCZRBVAVZTRLM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699453   

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM699453((S)-2-(3-(Acrylamidomethyl)-1-(4- (trifluoromethox...)
Affinity DataIC50: 3.60E+4nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM699453((S)-2-(3-(Acrylamidomethyl)-1-(4- (trifluoromethox...)
Affinity DataIC50: 5.00E+4nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM699453((S)-2-(3-(Acrylamidomethyl)-1-(4- (trifluoromethox...)
Affinity DataIC50: 5.00E+4nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM699453((S)-2-(3-(Acrylamidomethyl)-1-(4- (trifluoromethox...)
Affinity DataIC50: 5.00E+4nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent