BDBM703963 (S)-5-amino-N-((5-bromopyridin- 2-yl)methyl)-6-methyl-N-(1- (pyrimidin-2-yl)ethyl)-1H- pyrrolo[3,2-b]pyridine-2- carboxamide LCMS [M + 1]+ = 468.0. 1H NMR (400 MHz, DMSO-d6) $#948; = 11.66- 11.05 (m, 1H), 9.02-8.50 (m, 3H), 8.14-7.86 (m, 1H), 7.68- 7.13 (m, 3H), 6.73-6.00 (m, 1H), 5.34 (br s, 2H), 5.07-4.36 (m, 1H), 2.13 (br s, 3H), 1.72-1.52 (m, 3H)::US20240368153, Example 10-1

SMILES Cc1cc2[nH]c(C(=O)N(Cc3ccc(Br)cn3)[C@H](C)c3ncccn3)cc2nc1N

InChI Key InChIKey=JKULQMNXTLIXNY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 703963   

LigandChemical structure of BindingDB Monomer ID 703963BDBM703963((S)-5-amino-N-((5-bromopyridin- 2-yl)methyl)-6-met...)
Affinity DataIC50: 9.07E+3nMAssay Description:Table B2: The assay uses recombinant full-length histone H2A as the PRMT5 substrate. Enzymatic transfer of the tritiated methyl group from S-adenosyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 703963BDBM703963((S)-5-amino-N-((5-bromopyridin- 2-yl)methyl)-6-met...)
Affinity DataIC50: 9.07E+3nMAssay Description:Table B2: The assay uses recombinant full-length histone H2A as the PRMT5 substrate. Enzymatic transfer of the tritiated methyl group from S-adenosyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent