BDBM703965 (R)-5-amino-N-((5-bromopyridin- 2-yl)methyl)-6-methyl-N-(1- (pyrimidin-2-yl)ethyl)-1H- pyrrolo[3,2-b]pyridine-2- carboxamide LCMS [M + 1]+ = 468.0. 1H NMR (400 MHz, DMSO-d6) $#948; = 11.31 (br d, J = 3.2 Hz, 1H), 8.80 (br s, 3H), 8.12-7.86 (m, 1H), 7.54- 7.22 (m, 3H), 6.74-5.99 (m, 1H), 5.32 (br s, 2H), 5.12-4.30 (m, 1H), 2.13 (br s, 3H), 1.62 (br s, 2H), 1.23 (s, 3H)::US20240368153, Example 10-2

SMILES Cc1cc2[nH]c(C(=O)N(Cc3ccc(Br)cn3)[C@@H](C)c3ncccn3)cc2nc1N

InChI Key InChIKey=JKULQMNXTLIXNY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 703965   

LigandPNGBDBM703965((R)-5-amino-N-((5-bromopyridin- 2-yl)methyl)-6-met...)
Affinity DataIC50: 123nMAssay Description:Table B2: The assay uses recombinant full-length histone H2A as the PRMT5 substrate. Enzymatic transfer of the tritiated methyl group from S-adenosyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent