BDBM704643 US20240374606, Example 196::rel-(R)-3-[4-(Isopropylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide and rel-(S)-3-[4-(isopropylsulfonimidoyl)anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide

SMILES CNc2nc(Nc1ccc(S(=N)(=O)C(C)C)cc1)c(C(N)=O)nc2c3cncc4c3ncn4C

InChI Key InChIKey=FTMLQXAVSYTOLC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 704643   

LigandPNGBDBM704643(rel-(R)-3-[4-(Isopropylsulfonimidoyl)anilino]-5-(m...)
Affinity DataIC50: 3nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
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LigandPNGBDBM704643(rel-(R)-3-[4-(Isopropylsulfonimidoyl)anilino]-5-(m...)
Affinity DataIC50: 21nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
Astrazeneca

US Patent
LigandPNGBDBM704643(rel-(R)-3-[4-(Isopropylsulfonimidoyl)anilino]-5-(m...)
Affinity DataIC50: 679nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent