BDBM70487 6-amino-3-[(3-cyano-4,6-dimethylpyridin-2-yl)sulfanylmethyl]-4-(4-fluorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::6-amino-3-[[(3-cyano-4,6-dimethyl-2-pyridinyl)thio]methyl]-4-(4-fluorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::6-amino-3-[[(3-cyano-4,6-dimethyl-2-pyridyl)thio]methyl]-4-(4-fluorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::6-amino-3-{[(3-cyano-4,6-dimethyl-2-pyridinyl)sulfanyl]methyl}-4-(4-fluorophenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::6-azanyl-3-[(3-cyano-4,6-dimethyl-pyridin-2-yl)sulfanylmethyl]-4-(4-fluorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::MLS000594424::SMR000114667::cid_3252537

SMILES CNC(=O)c5cc1CCCc1c(N4CCCc3cc(c2cnn(C)c2)c(C(F)F)cc34)n5

InChI Key InChIKey=VJOANIGUTPTGCE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 70487   

TargetCREB-binding protein(Human)
Pharmablock Sciences (Nanjing)

US Patent
LigandChemical structure of BindingDB Monomer ID 70487BDBM70487(US12486251, Example 61)
Affinity DataIC50: 70nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2026
Entry Details Article
US Patent