BDBM708414 (S)-3-amino-6-(((1-(2-(2,4- difluorophenyl)-2-hydroxy-3- (1H-1,2,4-triazol-1- yl)propyl)piperidin-4- yl)amino)methyl)-1-(4-phenyl- 3,4-dihydro-2H- benzo[b][1,4]oxazin-6- yl)thieno[2,3-b]pyrazin-2(1H)- one::US20240424113, Compound I-63

SMILES c1ccc(cc1)N2CCOc3c2cc(cc3)N4c5cc(sc5N=C(C4=O)N)CNC6CCN(CC6)C[C@](Cn7cncn7)(c8ccc(cc8F)F)O

InChI Key InChIKey=PRCZCNBGHGABSD-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 708414   

TargetHeat shock protein 90 homolog(Yeast)
Bright Angel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 708414BDBM708414((S)-3-amino-6-(((1-(2-(2,4- difluorophenyl)-2-hydr...)
Affinity DataKd:  377nMAssay Description:Surface Plasmon Resonance (SPR) Experiments. SPR experiments were performed on a Biacore S200 instrument at 25° C. Biotinylated Hsp90 Nuclear Binding...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
5/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetHeat shock protein 90(Neosartorya fumigata)
Bright Angel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 708414BDBM708414((S)-3-amino-6-(((1-(2-(2,4- difluorophenyl)-2-hydr...)
Affinity DataKd:  591nMAssay Description:Surface Plasmon Resonance (SPR) Experiments. SPR experiments were performed on a Biacore S200 instrument at 25° C. Biotinylated Hsp90 Nuclear Binding...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
5/7/2025
Entry Details
US Patent