BDBM710716 (S)-2-(3-(6-(4-methyl-4H-1,2,4-triazol-3- yl)-2-oxaspiro[3.3]heptan-6-yl)phenyl)-6- ((3-methylpiperidin-1-yl)methyl)-4- (trifluoromethyl)isoindolin-1-one::US12187709, Compound 66

SMILES C[C@H]7CCCN(Cc6cc5C(=O)N(c4cccc(C3(c1nncn1C)CC2(COC2)C3)c4)Cc5c(C(F)(F)F)c6)C7

InChI Key InChIKey=KOOHGEPKDRNWTM-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710716   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710716BDBM710716((S)-2-(3-(6-(4-methyl-4H-1,2,4-triazol-3- yl)-2-ox...)
Affinity DataKd:  16nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710716BDBM710716((S)-2-(3-(6-(4-methyl-4H-1,2,4-triazol-3- yl)-2-ox...)
Affinity DataIC50: 25nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710716BDBM710716((S)-2-(3-(6-(4-methyl-4H-1,2,4-triazol-3- yl)-2-ox...)
Affinity DataIC50: 62.5nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710716BDBM710716((S)-2-(3-(6-(4-methyl-4H-1,2,4-triazol-3- yl)-2-ox...)
Affinity DataKd:  81nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent