BDBM710721 2-(6-(cyclobutylamino)-4-((S)-3-methyl-1- (4-methyl-4H-1,2,4-triazol-3-yl)cyclobut-2- en-1-yl)pyridin-2-yl)-6-(((S)-2-isopropyl-4- methylpiperazin-1-yl)methyl)-4- (trifluoromethyl)isoindolin-1-one::US12187709, Compound 71

SMILES CC1=C[C@@](c2cc(NC3CCC3)nc(N3Cc4c(cc(CN5CCN(C)C[C@@H]5C(C)C)cc4C(F)(F)F)C3=O)c2)(c2nncn2C)C1

InChI Key InChIKey=ILGMYQYCPUUOPG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710721   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710721BDBM710721(2-(6-(cyclobutylamino)-4-((S)-3-methyl-1- (4-methy...)
Affinity DataKd:  3.70nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710721BDBM710721(2-(6-(cyclobutylamino)-4-((S)-3-methyl-1- (4-methy...)
Affinity DataIC50: 14nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710721BDBM710721(2-(6-(cyclobutylamino)-4-((S)-3-methyl-1- (4-methy...)
Affinity DataIC50: 16.8nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710721BDBM710721(2-(6-(cyclobutylamino)-4-((S)-3-methyl-1- (4-methy...)
Affinity DataKd:  34nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent