BDBM710923 2-((1r,3r)-3-(4-methyl-4H-1,2,4-triazol-3- yl)-3-(3-(6-(((1- methylcyclobutyl)amino)methyl)-1-oxo-4- (trifluoromethyl)isoindolin-2- yl)phenyl)cyclobutoxy)acetontrile::US12187709, Compound 281

SMILES Cn1cnnc1[C@]1(c2cccc(N3Cc4c(cc(CNC5(C)CCC5)cc4C(F)(F)F)C3=O)c2)C[C@@H](OCC#N)C1

InChI Key InChIKey=KPSDPUDIOPLZOR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710923   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710923BDBM710923(2-((1r,3r)-3-(4-methyl-4H-1,2,4-triazol-3- yl)-3-(...)
Affinity DataKd:  1.10nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710923BDBM710923(2-((1r,3r)-3-(4-methyl-4H-1,2,4-triazol-3- yl)-3-(...)
Affinity DataIC50: 6.70nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710923BDBM710923(2-((1r,3r)-3-(4-methyl-4H-1,2,4-triazol-3- yl)-3-(...)
Affinity DataKd:  7nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710923BDBM710923(2-((1r,3r)-3-(4-methyl-4H-1,2,4-triazol-3- yl)-3-(...)
Affinity DataIC50: 9.5nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent