BDBM710958 2-(3-((S)-(4-methyl-4H-1,2,4-triazol-3- yl)(oxetan-3-yl)methyl)phenyl)-6-((R)-1- ((1-methylcyclobutyl)amino)propyl)-4- (trifluoromethyl)isoindolin-1-one::US12187709, Compound 316

SMILES CC[C@@H](NC1(C)CCC1)c1cc2c(c(C(F)(F)F)c1)CN(c1cccc([C@@H](c3nncn3C)C3COC3)c1)C2=O

InChI Key InChIKey=KHUHMPCMKSWRNR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710958   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710958BDBM710958(2-(3-((S)-(4-methyl-4H-1,2,4-triazol-3- yl)(oxetan...)
Affinity DataKd:  170nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710958BDBM710958(2-(3-((S)-(4-methyl-4H-1,2,4-triazol-3- yl)(oxetan...)
Affinity DataIC50: 270nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710958BDBM710958(2-(3-((S)-(4-methyl-4H-1,2,4-triazol-3- yl)(oxetan...)
Affinity DataKd:  1.30E+3nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710958BDBM710958(2-(3-((S)-(4-methyl-4H-1,2,4-triazol-3- yl)(oxetan...)
Affinity DataIC50: 3.10E+3nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent