BDBM711077 (R)-6-(((1-methylcyclobutyl)amino)methyl)- 2-(3-(oxetan-3-yl(1H-1,2,3-triazol-1- yl)methyl)phenyl)-4- (trifluoromethyl)isoindolin-1-one::US12187709, Compound 436

SMILES CC1(NCc2cc3c(c(C(F)(F)F)c2)CN(c2cccc([C@@H](C4COC4)n4ccnn4)c2)C3=O)CCC1

InChI Key InChIKey=QQUVFOWMNHSIRI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 711077   

LigandChemical structure of BindingDB Monomer ID 711077BDBM711077((R)-6-(((1-methylcyclobutyl)amino)methyl)- 2-(3-(o...)
Affinity DataIC50: 570nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 711077BDBM711077((R)-6-(((1-methylcyclobutyl)amino)methyl)- 2-(3-(o...)
Affinity DataKd:  600nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 711077BDBM711077((R)-6-(((1-methylcyclobutyl)amino)methyl)- 2-(3-(o...)
Affinity DataIC50: 2.40E+3nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 711077BDBM711077((R)-6-(((1-methylcyclobutyl)amino)methyl)- 2-(3-(o...)
Affinity DataKd:  3.50E+3nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent