BDBM711089 2-(3-((1s,3s)-3-methoxy-1-(4-methyl-4H- 1,2,4-triazol-3-yl)cyclobutyl)phenyl)-6-(((1- methylcyclobutyl)amino)methyl)isoindolin- 1-one::US12187709, Compound 448

SMILES CO[C@H]1C[C@@](c2cccc(N3Cc4ccc(CNC5(C)CCC5)cc4C3=O)c2)(c2nncn2C)C1

InChI Key InChIKey=RQVWDOMMFOUDTO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 711089   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 711089BDBM711089(2-(3-((1s,3s)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataKd:  420nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 711089BDBM711089(2-(3-((1s,3s)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataIC50: 730nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 711089BDBM711089(2-(3-((1s,3s)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataKd:  2.50E+3nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 711089BDBM711089(2-(3-((1s,3s)-3-methoxy-1-(4-methyl-4H- 1,2,4-tria...)
Affinity DataIC50: 3.90E+3nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent