BDBM71145 US9546164, 267::US9546164, 269::US9694002, 267::US9694002, 269

SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(CC2)[C@H](CO)c2cc(Cl)cc(Cl)c2)cc1F

InChI Key InChIKey=DHFLDZDCXCPNAT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 71145   

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71145(US9694002, 269 | US9694002, 267 | US9546164, 267 |...)
Affinity DataIC50: 2.60nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71145(US9694002, 269 | US9694002, 267 | US9546164, 267 |...)
Affinity DataIC50: 3.40nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

LigandPNGBDBM71145(US9694002, 269 | US9694002, 267 | US9546164, 267 |...)
Affinity DataIC50: 3.40nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71145(US9694002, 269 | US9694002, 267 | US9546164, 267 |...)
Affinity DataIC50: 47nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

LigandPNGBDBM71145(US9694002, 269 | US9694002, 267 | US9546164, 267 |...)
Affinity DataIC50: 47nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
US Patent