BDBM717557 US20250034165, Example 132

SMILES Cc1cc2cc(n1)-c1cnn(C)c1OCCC[C@@H](C1CC1)CN1/C(=N/C2=O)Nc2ccc(N[C@H]3CC[C@@H](N(C)C)C3)cc21

InChI Key InChIKey=GEAIPWDCEYEYCJ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 717557   

TargetEpidermal growth factor receptor (EGFR)(L858R)(T790M)(Human)
Chia Tai Tianqing Pharmaceutical Group Co.

US Patent
LigandPNGBDBM717557(US20250034165, Example 132)
Affinity DataIC50: 0.0820nMAssay Description:A 50 ng/μL EGFR (L858R/T790M, Carna) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Tween 20),...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group Co.

US Patent
LigandPNGBDBM717557(US20250034165, Example 132)
Affinity DataIC50: 0.0630nMAssay Description:A 50 ng/μL EGFR (L858R/T790M/C797S, BPS) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Tween ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-745,751-1210,T790M,C797S](Human)
Chia Tai Tianqing Pharmaceutical Group Co.

US Patent
LigandPNGBDBM717557(US20250034165, Example 132)
Affinity DataIC50: 0.0660nMAssay Description:A 50 ng/μL EGFR (d746-750/T790M/C797S, BPS) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Twe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent