BDBM719790 N-methyl-N-((5-(2-((1-methyl-1H- pyrazolo[3,4-d]pyrimidin-4- yl)thio)acetyl)thiophen-2- yl)methyl)-1-(pyridin-4- yl)methanesulfonamide::US20250051319, Compound 92

SMILES CN(Cc1ccc(C(=O)CSc2ncnc3c2cnn3C)s1)S(=O)(=O)Cc1ccncc1

InChI Key InChIKey=KMUICQAKFBTJNT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 719790   

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719790(N-methyl-N-((5-(2-((1-methyl-1H- pyrazolo[3,4-d]py...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HDAC enzymes was performed in 384-well plate format using human full-length recombinant HDAC1 and HDAC6, isolated from a baculovirus ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719790(N-methyl-N-((5-(2-((1-methyl-1H- pyrazolo[3,4-d]py...)
Affinity DataIC50: 300nMAssay Description:NanoBRET target engagement was performed against the catalytic domain 2 (CD2) of HDAC6, with minor modifications of kit manufacturer protocol (Promeg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719790(N-methyl-N-((5-(2-((1-methyl-1H- pyrazolo[3,4-d]py...)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of HDAC enzymes was performed in 384-well plate format using human full-length recombinant HDAC1 and HDAC6, isolated from a baculovirus ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent