BDBM726539 5-[4-[(2-ethyl-5-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl]-N-methyl-pyridine-2-carboxamide::US20250082630, Example 44

SMILES CCc1nc2ccc(CN3CCN(c4ccc(C(=O)NC)nc4)CC3)c(C)c2[nH]c1=O

InChI Key InChIKey=FSSXWGUOQSMNNN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 726539   

TargetPoly [ADP-ribose] polymerase 1(Human)
AstraZeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 726539BDBM726539(5-[4-[(2-ethyl-5-methyl-3-oxo-4H-quinoxalin-6-yl)m...)
Affinity DataIC50: 128nMAssay Description:Recombinant full length 6HIS tagged PARP1 protein was diluted to 6 nM with 50 mM Tris pH 8, 0.001% Triton X100, 10 mM MgCl2, 150 mM NaCl and incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/16/2025
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
AstraZeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 726539BDBM726539(5-[4-[(2-ethyl-5-methyl-3-oxo-4H-quinoxalin-6-yl)m...)
Affinity DataIC50: 1.00E+5nMAssay Description:Recombinant full length 6HIS tagged PARP1 protein was diluted to 6 nM with 50 mM Tris pH 8, 0.001% Triton X100, 10 mM MgCl2, 150 mM NaCl and incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/16/2025
Entry Details
US Patent