BDBM731027 4-(1,4-dioxan-2-yl)-N-{6-[(3-ethyl-1H-pyrazol-5-yl)amino]-5-methoxy-1,2-benzoxazol-3-yl}-2,6-dimethoxybenzene-1-sulfonamide::US20250122183, Example 240

SMILES CCc1cc(Nc2cc3onc(NS(=O)(=O)c4c(OC)cc([C@@H]5COCCO5)cc4OC)c3cc2OC)[nH]n1

InChI Key InChIKey=OADRUKANCREWTO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 731027   

TargetHistone acetyltransferase KAT6A(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 731027BDBM731027(4-(1,4-dioxan-2-yl)-N-{6-[(3-ethyl-1H-pyrazol-5-yl...)
Affinity DataKi:  1.20nMAssay Description:1. Final reaction conditions are 2.5 nM KAT6A Full length enzyme, 25 μM AcCoA,2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200 nL of dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 731027BDBM731027(4-(1,4-dioxan-2-yl)-N-{6-[(3-ethyl-1H-pyrazol-5-yl...)
Affinity DataKi:  7.5nMAssay Description:1. Final reaction conditions are 4 nM KAT7+JADE1+EAF6+ING5 4-protein complex, 1 μM AcCoA, 2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent