BDBM7319 6-Oxo-5,6,7,12-tetrahydro-indolo[3,2-d][1]benzazepine-2-carbonitrile::9-oxo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaene-4-carbonitrile::NSC 708243::Paullone Analogue 54

SMILES O=C1Cc2c([nH]c3ccccc23)-c2cc(ccc2N1)C#N

InChI Key InChIKey=UQYAOCPYYWTPID-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7319   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Universitat Hamburg

LigandPNGBDBM7319(NSC 708243 | 9-oxo-8,18-diazatetracyclo[9.7.0.0^{2...)
Affinity DataIC50: 3.30E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Universitat Hamburg

LigandPNGBDBM7319(NSC 708243 | 9-oxo-8,18-diazatetracyclo[9.7.0.0^{2...)
Affinity DataIC50: 4.50E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Universitat Hamburg

LigandPNGBDBM7319(NSC 708243 | 9-oxo-8,18-diazatetracyclo[9.7.0.0^{2...)
Affinity DataIC50: 1.30E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2006
Entry Details Article
PubMed