BDBM743631 3-(5-(2-((1-(1-(5-chloro- 4-((1-methyl-2-oxo-3-(2- oxopropoxy)-1,2- dihydroquinolin-6- yl)amino)pyrimidin-2- yl)piperidin-4- yl)pyrrolidin-3-yl) (methyl)amino)ethoxy)- 1-oxoisoindolin-2- yl)piperidine-2,6-dione::US12310975, Example 157

SMILES CC(=O)COc1cc2cc(Nc3nc(N4CCC(N5CCC(N(C)CCOc6ccc7c(c6)CN(C6CCC(=O)NC6=O)C7=O)C5)CC4)ncc3Cl)ccc2n(C)c1=O

InChI Key InChIKey=PYJGIZVBYHIZJY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743631   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743631BDBM743631(3-(5-(2-((1-(1-(5-chloro- 4-((1-methyl-2-oxo-3-(2-...)
Affinity DataIC50: 10nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent