BDBM743633 (2S,4R)-N-(2-(4-((1-(5- chloro-4-((1-methyl-3-(2- (methylamino)-2- oxoethoxy)-2-oxo-1,2- dihydroquinolin-6- yl)amino)pyrimidin-2- yl)piperidin-4- yl)oxy)butoxy)-4-(4- methylthiazol-5- yl)benzyl)-4-hydroxy-1- (3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine- 2-carboxamide::US12310975, Example 159

SMILES CNC(=O)COc1cc2cc(Nc3nc(N4CCC(OCCCCOc5cc(-c6scnc6C)ccc5CNC(=O)[C@@H]5C[C@@H](O)CN5C(=O)C(c5cc(C)no5)C(C)C)CC4)ncc3Cl)ccc2n(C)c1=O

InChI Key InChIKey=UXACSRZMRHRYJR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743633   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743633BDBM743633((2S,4R)-N-(2-(4-((1-(5- chloro-4-((1-methyl-3-(2- ...)
Affinity DataIC50: 30nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent