BDBM743655 5-(3-((5-chloro-4-((1- methyl-2-oxo-3-(2- oxopropoxy)-1,2- dihydroquinolin-6- yl)amino)pyrimidin-2- yl)ethynyl)piperidin-1- yl)-2-(2,6-dioxopiperidin- 3-yl)isoindoline-1,3- dione::US12310975, Example 181

SMILES CC(=O)COc1cc2cc(Nc3nc(C#CC4CCCN(c5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)ncc3Cl)ccc2n(C)c1=O

InChI Key InChIKey=MOUQXYDVKFKKKH-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743655   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743655BDBM743655(5-(3-((5-chloro-4-((1- methyl-2-oxo-3-(2- oxopropo...)
Affinity DataIC50: 100nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent