BDBM743722 5-(4-((1-(5-chloro-4-((1- methyl-3-(((R)-1-methyl- 2-oxopyrrolidin-3- yl)oxy)-2-oxo-1,2- dihydroquinolin-6- yl)amino)pyrimidin-2- yl)piperidin-4- yl)methyl)piperazin-1- yl)-2-(2,6-dioxopiperidin- 3-yl)isoindoline-1,3- dione::US12310975, Example 258

SMILES CN1CC[C@@H](Oc2cc3cc(Nc4nc(N5CCC(CN6CCN(c7ccc8c(c7)C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)CC5)ncc4Cl)ccc3n(C)c2=O)C1=O

InChI Key InChIKey=SEZJFWNOMSOENW-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743722   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743722BDBM743722(5-(4-((1-(5-chloro-4-((1- methyl-3-(((R)-1-methyl-...)
Affinity DataIC50: 100nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent