BDBM743829 2-({6-[(5-chloro-2-{4- [(3S,5R)-5-({[2-(2,6- dioxopiperidin-3-yl)-1,3- dioxo-2,3-dihydro-1H- isoindol-5- yl]oxy}methyl)-1- methylpyrrolidin-3- yl]piperazin-1- yl}pyrimidin-4- yl)amino]-1-ethyl-2-oxo- 1,2-dihydroquinolin-3- yl}oxy)-N- methylacetamide::US12310975, Example 371

SMILES CCn1c(=O)c(OCC(=O)NC)cc2cc(Nc3nc(N4CCN([C@H]5C[C@H](COc6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)N(C)C5)CC4)ncc3Cl)ccc21

InChI Key InChIKey=COZVJQCFBZUVHE-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743829   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743829BDBM743829(2-({6-[(5-chloro-2-{4- [(3S,5R)-5-({[2-(2,6- dioxo...)
Affinity DataIC50: 100nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent