BDBM743853 3-[7-({5-chloro-2-[4-({1- [2-(2,6-dioxopiperidin-3- yl)-1,3-dioxo-2,3- dihydro-1H-isoindol-5- yl]piperidin-4- yl}methyl)piperazin-1- yl]pyrimidin-4- yl}amino)-3-oxo-1,2,3,4- tetrahydroisoquinolin-2- yl]-N- methylpropanamide::US12310975, Example 395

SMILES CNC(=O)CCN1Cc2cc(Nc3nc(N4CCN(CC5CCN(c6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc2CC1=O

InChI Key InChIKey=QUUOOIDPTMDMOE-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743853   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743853BDBM743853(3-[7-({5-chloro-2-[4-({1- [2-(2,6-dioxopiperidin-3...)
Affinity DataIC50: 1.00E+3nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent