BDBM743860 2-{[6-({5-chloro-2-[4- ({1-[2-(2,6- dioxopiperidin-3-yl)-6- methoxy-1,3-dioxo-2,3- dihydro-1H-isoindol-5- yl]piperidin-4- yl}methyl)piperazin-1- yl]pyrimidin-4- yl}amino)-2-oxo-1- (propan-2-yl)-1,2- dihydroquinolin-3- yl]oxy}-N- methylacetamide::US12310975, Example 404

SMILES CNC(=O)COc1cc2cc(Nc3nc(N4CCN(CC5CCN(c6cc7c(cc6OC)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc2n(C(C)C)c1=O

InChI Key InChIKey=ODEMERZBRXELKR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 743860   

TargetB-cell lymphoma 6 protein(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 743860BDBM743860(2-{[6-({5-chloro-2-[4- ({1-[2-(2,6- dioxopiperidin...)
Affinity DataIC50: 30nMAssay Description:Assay buffer A: 50 mM HEPES pH 7.5, 125 mM NaCl, 0.01% TritonX.Assay buffer B (made fresh): buffer A+1 mM Glutathione (or 0.5 mM DTT).Assay buffer C ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent