BDBM747665 US12325697, Compound AKU-2

SMILES CCC1(NCc2cc3c(c(C(F)(F)F)c2)CN(c2cc(-c4ccc(C#N)cc4-c4nncn4C)cc(C4CC4)n2)C3=O)CC1

InChI Key InChIKey=MEHPIMUYHBAOFX-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 747665   

LigandChemical structure of BindingDB Monomer ID 747665BDBM747665(US12325697, Compound AKU-2)
Affinity DataIC50: 200nMAssay Description:Fluorescein-BODIPY labeled UBED2D(C85K)-Ub was prepared by conjugating ubiquitin (Ub) labeled at its N-terminus with Fluorescein-BODIPY maleimide (Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C [47-435](Human)
Nimbus Clio

US Patent
LigandChemical structure of BindingDB Monomer ID 747665BDBM747665(US12325697, Compound AKU-2)
Affinity DataIC50: 200nMAssay Description:Recombinant human c-Cbl (aa 47-435) was expressed in E. coli, purified and biotinylated in vitro. The protein was diluted to 12 nM in freshly prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent