BDBM749836 (7R)-7-amino-7-[1-(2-methyl- 2H-indazol-5-yl)-1H-pyrazol- 3-yl]-1-(1,3-oxazol-2- yl)heptan-1-one::US12331044, Example 127

SMILES Cn1cc2cc(-n3ccc([C@H](N)CCCCCC(=O)c4ncco4)n3)ccc2n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 749836   

TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM749836((7R)-7-amino-7-[1-(2-methyl- 2H-indazol-5-yl)-1H-p...)
Affinity DataIC50: 480nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 3(Human)TBA
LigandPNGBDBM749836((7R)-7-amino-7-[1-(2-methyl- 2H-indazol-5-yl)-1H-p...)
Affinity DataIC50: 770nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 2(Human)TBA
LigandPNGBDBM749836((7R)-7-amino-7-[1-(2-methyl- 2H-indazol-5-yl)-1H-p...)
Affinity DataIC50: 2.60E+3nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details