BDBM749843 (7S)-7-amino-7-[5-(2,5- difluorophenyl)-1H-imidazol-2-yl]- 1-(1,3-oxazol-2-yl)heptan-1-one::US12331044, Example 135

SMILES N[C@@H](CCCCCC(=O)c1ncco1)c1ncc(-c2cc(F)ccc2F)[nH]1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 749843   

TargetHistone deacetylase 3(Human)TBA
LigandPNGBDBM749843((7S)-7-amino-7-[5-(2,5- difluorophenyl)-1H-imidazo...)
Affinity DataIC50: 85nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM749843((7S)-7-amino-7-[5-(2,5- difluorophenyl)-1H-imidazo...)
Affinity DataIC50: 91nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 2(Human)TBA
LigandPNGBDBM749843((7S)-7-amino-7-[5-(2,5- difluorophenyl)-1H-imidazo...)
Affinity DataIC50: 450nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM749843((7S)-7-amino-7-[5-(2,5- difluorophenyl)-1H-imidazo...)
Affinity DataIC50: 900nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM749843((7S)-7-amino-7-[5-(2,5- difluorophenyl)-1H-imidazo...)
Affinity DataIC50: 900nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details