BDBM749867 N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H- imidazol-2-yl]-7-(1,3-oxazol-2- yl)-7-oxoheptyl]-2-(2- oxopiperazin-1-yl)acetamide::US12331044, Example 159

SMILES COc1cc2nc(C)ccc2cc1-c1cnc([C@H](CCCCCC(=O)c2ncco2)NC(=O)CN2CCNCC2=O)[nH]1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 749867   

TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM749867(N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H...)
Affinity DataIC50: 0.820nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 3(Human)TBA
LigandPNGBDBM749867(N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H...)
Affinity DataIC50: 1.70nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 2(Human)TBA
LigandPNGBDBM749867(N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H...)
Affinity DataIC50: 5.80nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM749867(N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H...)
Affinity DataIC50: 58nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM749867(N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H...)
Affinity DataIC50: 2.90E+3nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details