BDBM749870 N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H- imidazol-2-yl]-7-(1,3-oxazol-2- yl)-7-oxoheptyl]-2-(1H-pyrrol-1- yl)acetamide::US12331044, Example 162

SMILES COc1cc2nc(C)ccc2cc1-c1cnc([C@H](CCCCCC(=O)c2ncco2)NC(=O)Cn2cccc2)[nH]1

InChI Key InChIKey=QBWTZABUPQHVIG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 749870   

TargetHistone deacetylase 3(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM749870(N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H...)
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/9/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM749870(N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H...)
Affinity DataIC50: 4.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/9/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM749870(N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H...)
Affinity DataIC50: 24nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/9/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM749870(N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H...)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/9/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM749870(N-[(1S)-1-[5-(7-methoxy-2- methylquinolin-6-yl)-1H...)
Affinity DataIC50: 900nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/9/2025
Entry Details
Go to US Patent